反応式
[CH3:1][C:2]([CH3:12])([O:4][C:5]([NH:7][CH2:8][C:9]([OH:11])=O)=[O:6])[CH3:3].[CH:13]1([N:19]=C=NC2CCCCC2)CCCC[CH2:14]1.[C:28]1([CH2:34][O:35][C:36]2[CH:41]=[CH:40][C:39](CCN)=[CH:38][CH:37]=2)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>O1CCCC1>[C:28]1([CH2:34][O:35][C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][C:41]=2[CH2:14][CH2:13][NH:19][C:9](=[O:11])[CH2:8][NH:7][C:5]([O:4][C:2]([CH3:1])([CH3:3])[CH3:12])=[O:6])[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1参加物
実験手順
N-(1,1-Dimethylethoxycarbonyl)glycine N-(2-(4-phenylmethoxy)phenyl)ethyl)amide. N-(1,1-Dimethylethoxycarbonyl)glycine (850 mg, 4.85 mmol) was stirred with dicyclohexylcarbodiimide (1.00 g, 4.85 mmol) and 2-(4-(phenylmethoxy)phenyl)ethylamine (Intermediate C) (1.00 g, 4.4 mmol) in dry tetrahydrofuran (30 mL) for 16 h. The suspension was filtered and the solvent was evaporated from the filtrate under reduced pressure. The residue was dissolved in ethyl acetate and was washed with aqueous sulphuric acid (10%) and with saturated brine. The solution was dried with anhydrous magnesium sulphate and the solvent was evaporated under reduced pressure to give N-(1,1dimethylethoxycarbonyl)glycine N-(2-(-(phenylmethoxy)phenyl)ethyl)amide (1.65 g, 98%).
後処理
- filtrationThe suspension was filtered
- customthe solvent was evaporated from the filtrate under reduced pressure
- dissolutionThe residue was dissolved in ethyl acetate
- washwas washed with aqueous sulphuric acid (10%) and with saturated brine
- dry with materialThe solution was dried with anhydrous magnesium sulphate
- customthe solvent was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-6078d91084014e80b9e9af5fb94aaee3
- 出典データセット
- uspto-grants-1997_04
- 特許番号
- US05618528
関連ノート
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