Triethylsilane → N-(3-(2-fluorobenzyl)-3-hydroxycyclohexyl)-3-(2-methylpyridin-4-yl)4H-indazole-5-carboxamide
反応式
[F:1][C:2]1[CH:53]=[CH:52][CH:51]=[CH:50][C:3]=1[CH2:4][C:5]1([OH:49])[CH2:10][CH2:9][CH2:8][CH:7]([NH:11][C:12]([C:14]2[CH:15]=[C:16]3[C:20](=[CH:21][CH:22]=2)[N:19](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[N:18]=[C:17]3[C:42]2[CH:47]=[CH:46][N:45]=[C:44]([CH3:48])[CH:43]=2)=[O:13])[CH2:6]1.[SiH](CC)(CC)CC>C(O)(C(F)(F)F)=O>[F:1][C:2]1[CH:53]=[CH:52][CH:51]=[CH:50][C:3]=1[CH2:4][C:5]1([OH:49])[CH2:10][CH2:9][CH2:8][CH:7]([NH:11][C:12]([C:14]2[CH2:15][C:16]3[C:20](=[CH:21][CH:22]=2)[N:19]=[N:18][C:17]=3[C:42]2[CH:47]=[CH:46][N:45]=[C:44]([CH3:48])[CH:43]=2)=[O:13])[CH2:6]1参加物
4
実験手順
N-(3-(2-fluorobenzyl)-3-hydroxycyclohexyl)-3-(2-methylpyridin-4-yl)-1-trityl-1H-indazole-5-carboxamide was stirred in neat TFA at room temperature for 10 minutes, and then Et3SiH (5 equiv.) was added. The reaction mixture was stirred at room temperature for 5 minutes, and then concentrated. The titled compound was obtained and purified by reverse phase HPLC.