Triethylsilane → N-(3-(2-fluorobenzyl)-3-methoxycyclohexyl)-3-(2-methylpyridin-4-yl)-1H-indazole-5-carboxamide

HRID 530848ノート

反応式

HRID 530848 の反応式
[F:1][C:2]1[CH:54]=[CH:53][CH:52]=[CH:51][C:3]=1[CH2:4][C:5]1([O:49][CH3:50])[CH2:10][CH2:9][CH2:8][CH:7]([NH:11][C:12]([C:14]2[CH:15]=[C:16]3[C:20](=[CH:21][CH:22]=2)[N:19](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[N:18]=[C:17]3[C:42]2[CH:47]=[CH:46][N:45]=[C:44]([CH3:48])[CH:43]=2)=[O:13])[CH2:6]1.[SiH](CC)(CC)CC>C(O)(C(F)(F)F)=O>[F:1][C:2]1[CH:54]=[CH:53][CH:52]=[CH:51][C:3]=1[CH2:4][C:5]1([O:49][CH3:50])[CH2:10][CH2:9][CH2:8][CH:7]([NH:11][C:12]([C:14]2[CH:15]=[C:16]3[C:20](=[CH:21][CH:22]=2)[NH:19][N:18]=[C:17]3[C:42]2[CH:47]=[CH:46][N:45]=[C:44]([CH3:48])[CH:43]=2)=[O:13])[CH2:6]1

参加物

4

反応物 2

HCID 12052TriethylsilaneHCID 67984947N-(3-(2-fluorobenzyl)-3-methoxycyclohexyl)-3-(2-methylpyridin-4-yl)-1-trityl-1H-indazole-5-carboxamide

生成物 1

HCID 57410417N-(3-(2-fluorobenzyl)-3-methoxycyclohexyl)-3-(2-methylpyridin-4-yl)-1H-indazole-5-carboxamide

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

N-(3-(2-fluorobenzyl)-3-methoxycyclohexyl)-3-(2-methylpyridin-4-yl)-1-trityl-1H-indazole-5-carboxamide was stirred in neat TFA at room temperature for 10 minutes, and then Et3SiH (5 equiv.) was added. The reaction mixture was stirred at room temperature for 5 minutes, and then concentrated. The product was obtained and purified by reverse phase HPLC. Two diastereomers obtained.

後処理

  1. concentrationconcentrated
  2. customThe product was obtained
  3. custompurified by reverse phase HPLC
  4. customTwo diastereomers obtained

出典と根拠

ORDレコード
ord-fa8ad612ab3840eebea1e3c22de9926c
出典データセット
uspto-grants-2016_05
特許番号
US09351965B2

反応ノート

読み込み中…