Hydrochloric Acid → Methyl 3-amino-1-(4-fluorobenzyl)cyclohexanecarboxylate
反応式
Cl.C1(C(=[N:15][CH:16]2[CH2:21][CH2:20][CH2:19][C:18]([CH2:26][C:27]3[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=3)([C:22]([O:24][CH3:25])=[O:23])[CH2:17]2)C2C=CC=CC=2)C=CC=CC=1>O1CCCC1>[NH2:15][CH:16]1[CH2:21][CH2:20][CH2:19][C:18]([CH2:26][C:27]2[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=2)([C:22]([O:24][CH3:25])=[O:23])[CH2:17]1参加物
4
実験手順
In a flask, methyl 3-(diphenylmethyleneamino)-1-(4-fluorobenzyl)cyclohexanecarboxylate (crude, from previous step) was dissolved in tetrahydrofuran (15 mL). Concentrated hydrochloric acid (1.2 mL) was added to the reaction. The reaction was stirred at room temperature for 5 hours. The resulting reaction mixture was concentrated to yield the crude product. The crude product was progressed to the next step without further purification.