Hydrochloric Acid → Ethyl 5-oxo-6-(piperidin-4-yl)-2-propyl-5,6,7,8-tetrahydro-1,6-naphthyridine-3-carboxylate dihydrochloride monohydrate

HRID 531091ノート

反応式

HRID 531091 の反応式
C([O:5]C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:23][CH2:22][C:21]3[N:20]=[C:19]([CH2:24][CH2:25][CH3:26])[C:18]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:17][C:16]=3[C:15]2=[O:32])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:33].C(OC(C)C)(C)C>>[OH2:5].[ClH:33].[ClH:33].[O:32]=[C:15]1[N:14]([CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH2:23][CH2:22][C:21]2[N:20]=[C:19]([CH2:24][CH2:25][CH3:26])[C:18]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:17][C:16]1=2

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 7914Diisopropyl EtherHCID 117992199Ethyl 6-(1-(tert-butoxycarbonyl)piperidin-4-yl)-5-oxo-2-propyl-5,6,7,8-tetrahydro-1,6-naphthyridine-3-carboxylate

生成物 1

HCID 131735653Ethyl 5-oxo-6-(piperidin-4-yl)-2-propyl-5,6,7,8-tetrahydro-1,6-naphthyridine-3-carboxylate dihydrochloride monohydrate

実験手順

Ethyl 6-(1-(tert-butoxycarbonyl)piperidin-4-yl)-5-oxo-2-propyl-5,6,7,8-tetrahydro-1,6-naphthyridine-3-carboxylate (14.9 g) was added to 2M hydrogen chloride (ethanol solution, 167 mL) at room temperature. The mixture was stirred for 4 hours. Diisopropyl ether (1.00 L) was added to the reaction mixture. The mixture was stirred for 30 minutes. The precipitate was collected by filtration, washed with diisopropyl ether, dried under reduced pressure to give the title compound (13.7 g).

後処理

  1. stirringThe mixture was stirred for 30 minutes
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with diisopropyl ether
  4. customdried under reduced pressure

出典と根拠

ORDレコード
ord-bcbcb6f777bc41a69212bbeda5a28240
出典データセット
uspto-grants-2016_05
特許番号
US09353108B2

反応ノート

読み込み中…