Lithium Hydroxide → 2-Cyclohexyl-1,3-thiazole-4-carboxylic acid

HRID 531365ノート

反応式

HRID 531365 の反応式
C([O:3][C:4]([C:6]1[N:7]=[C:8]([CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[S:9][CH:10]=1)=[O:5])C.[Li+].[OH-]>O>[CH:11]1([C:8]2[S:9][CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=2)[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1

参加物

4

反応物 2

HCID 3939Lithium HydroxideHCID 57956421Ethyl 2-cyclohexylthiazole-4-carboxylate

生成物 1

HCID 234049342-Cyclohexyl-1,3-thiazole-4-carboxylic acid収率 83%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of 2-cyclohexylthiazole-4-carboxylic acid ethyl ester (116, 6.8 g, 28.5 mmol) in water was added 1M LiOH (50 mL). The solution was kept at room temperature and monitored by LC-MS. When the hydrolysis was completed the reaction mixture was neutralized with myriatic acid and extracted with ethyl acetate and diethyl ether. The organic phase was dried (Na2SO4), filtered and concentrated under reduced pressure to give 5.0 g (83%) of the title compound 117: m/z=212 (M+H)+.

後処理

  1. customwas kept at room temperature
  2. extractionextracted with ethyl acetate and diethyl ether
  3. dry with materialThe organic phase was dried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-681754614e7842eb97311ad470f8177b
出典データセット
uspto-grants-2016_05
特許番号
US09353103B2

反応ノート

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