Triethylamine → 5-bromo-2-methoxy-N-methylbenzenesulfonamide
反応式
Cl.CN.[CH2:4]([N:6](CC)CC)C.[Br:11][C:12]1[CH:13]=[CH:14][C:15]([O:22][CH3:23])=[C:16]([S:18](Cl)(=[O:20])=[O:19])[CH:17]=1>C(Cl)Cl>[Br:11][C:12]1[CH:13]=[CH:14][C:15]([O:22][CH3:23])=[C:16]([S:18]([NH:6][CH3:4])(=[O:20])=[O:19])[CH:17]=1参加物
5
実験手順
To a stirred ice cold mixture of methylamine hydrochloride (231.1 mg, 3.5 mmol), triethylamine (1.26 mL, 8.755 mmol) in DCM was added a solution of 5-bromo-2-methoxybenzene-1-sulfonyl chloride (500 mg, 1.751 mmol) in DCM at 0° C. This was stirred at RT for three hours. This mixture was then poured on to ice cold water and extracted with DCM, dried over sodium sulfate and concentrated to get 400 mg (81.63% yield) of titled compound.
後処理
- additionThis mixture was then poured on to ice cold water
- extractionextracted with DCM
- dry with materialdried over sodium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-a6df682d67b54c1591f8da11e2e9de8e
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09353107B2
反応ノート
読み込み中…