Cyclohexanol → Cyclohexyl Hydrogen Phenylmalonate

HRID 53198

反応式

HRID 53198 の反応式
[C:1]1([CH:7]([C:11]([OH:13])=[O:12])[C:8]([OH:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)(Cl)=O.[CH:18]1(O)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1>CCOCC.CN(C)C=O>[C:1]1([CH:7]([C:11]([OH:13])=[O:12])[C:8]([O:10][CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

6

反応物 3

HCID 7966CyclohexanolHCID 24386Thionyl ChlorideHCID 75791Phenylmalonic acid

生成物 1

HCID 19042990Cyclohexyl Hydrogen Phenylmalonate

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 3283Diethyl Ether溶媒

実験手順

Phenylmalonic acid (13.5 g, 0.07 mol) in dry ether (40 mL) was treated with thionyl chloride (8.92 g, 5.4 mL, 0.07 mol) and one drop of N,N-dimethylformamide. The mixture was heated at 40°-50° C. for 3 hours. The clear solution was distilled under vacuum. The oily residue was redissolved in dry ether (40 mL), the solution was treated with cyclohexyl alcohol (0.075 mol), 7.9 mL) and refluxed for 2 hours. The mixture was worked up as before to give an oily product which crystallized on standing. Recrystallization was carried out from a benzene-petroleum ether (40°-60°) mixture to give a white crystalline product.

後処理

  1. temperatureThe mixture was heated at 40°-50° C. for 3 hours
  2. distillationThe clear solution was distilled under vacuum
  3. dissolutionThe oily residue was redissolved in dry ether (40 mL)
  4. temperaturerefluxed for 2 hours
  5. customto give an oily product which
  6. customcrystallized
  7. customRecrystallization
  8. customwas carried out from a benzene-petroleum ether (40°-60°) mixture
  9. customto give a white crystalline product

出典と根拠

ORDレコード
ord-4f01c620be9f4001a84e5ba6c5b4be16
出典データセット
uspto-grants-1997_04
特許番号
US05618826

関連ノート

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