2,2,2-Trifluoroethanol → 1,3-Dichloro-5-nitro-2-(2,2,2-trifluoroethoxy)benzene

A Mixture of Cs2CO3 (17.22 g, 52.84 mmol), CuBr (361 mg, 2.52 mmol) and ethyl 2-oxocyclohexanecarboxylate (856 mg, 5.03 mmol) in DMSO (30 mL) under N2 was stirred for 0.5 h at rt. Then a solution of 1,3-dichloro-2-iodo-5-nitrobenzene (8.0 g, 25.16 mmol) and 2,2,2-trifluoroethanol (3.02 g, 30.19 mmol) in DMSO (20 mL) was added to it. The reaction mixture was stirred at 80° C. for 18 h and cooled to room temperature, and then directly passed through celite. After rinsed with 250 ml of EA, the combined filter was washed by brine, dried over anhydrous Na2SO4, concentrated under reduced pressure. The residue was purified by column chromatography over silica gel eluted with PE:EA (100:1) to provide 1,3-dichloro-5-nitro-2-(2,2,2-trifluoroethoxy)benzene (1.93 g, yield 12.6%) as pale yellow solid.

1. stirringThe reaction mixture was stirred at 80° C. for 18 h
2. temperaturecooled to room temperature
3. washAfter rinsed with 250 ml of EA
4. filtrationthe combined filter
5. washwas washed by brine
6. dry with materialdried over anhydrous Na2SO4
7. concentrationconcentrated under reduced pressure
8. customThe residue was purified by column chromatography over silica gel
9. washeluted with PE

ORDレコード

ord-c2c96e8aeee44567aec83a1e90f1aa1b

出典データセット

uspto-grants-2014_10

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08853186B2