tert-Butyl 2-(5-fluoro-2-nitrophenoxy)propylcarbamate → tert-Butyl 2-(2-amino-5-fluorophenoxy)propylcarbamate

HRID 532256ノート

反応式

HRID 532256 の反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:20]([O-])=O)=[C:6]([CH:19]=1)[O:7][CH:8]([CH3:18])[CH2:9][NH:10][C:11](=[O:17])[O:12][C:13]([CH3:16])([CH3:15])[CH3:14]>CO.[Pd]>[NH2:20][C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:19][C:6]=1[O:7][CH:8]([CH3:18])[CH2:9][NH:10][C:11](=[O:17])[O:12][C:13]([CH3:14])([CH3:15])[CH3:16]

参加物

4

反応物 1

HCID 58413346tert-Butyl 2-(5-fluoro-2-nitrophenoxy)propylcarbamate

生成物 1

HCID 58413393tert-Butyl 2-(2-amino-5-fluorophenoxy)propylcarbamate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of tert-butyl 2-(5-fluoro-2-nitrophenoxy)propylcarbamate (3.1 g) in MeOH (5 ml) was added 10% palladium on carbon (300 mg) and the reaction mixture was hydrogenated at room temperature at 50 psi. The catalyst was filtered off and the filtrate was concentrated in vacuo.

後処理

  1. customwas hydrogenated at room temperature at 50 psi
  2. filtrationThe catalyst was filtered off
  3. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-be0d9773c66443df96f624b4727ffac0
出典データセット
uspto-grants-2014_10
特許番号
US08853193B2

反応ノート

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