Trifluoroacetic acid → HCID 67395207、化合物
反応式
[C:1]([C:4]1[S:32][C:7]2[N:8]=[CH:9][N:10]=[C:11]([NH:12][C:13]3[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:14]=3[O:15][CH:16]([CH3:26])[CH2:17][NH:18]C(=O)OC(C)(C)C)[C:6]=2[C:5]=1[CH3:33])(=[O:3])[NH2:2].[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37]>ClCCl>[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37].[NH2:18][CH2:17][CH:16]([O:15][C:14]1[CH:27]=[C:28]([F:31])[CH:29]=[CH:30][C:13]=1[NH:12][C:11]1[C:6]2[C:5]([CH3:33])=[C:4]([C:1]([NH2:2])=[O:3])[S:32][C:7]=2[N:8]=[CH:9][N:10]=1)[CH3:26]参加物
4
実験手順
tert-Butyl 2-(2-(6-carbamoyl-5-methylthieno[2,3-d]pyrimidin-4-ylamino)-5-fluorophenoxy)propylcarbamate (740 mg) was dissolved in dichloromethane (20 ml) and trifluoroacetic acid (4 ml) was added and the reaction was stirred at room temperature overnight. The reaction was concentrated in vacuo to give the title compound.
後処理
- concentrationThe reaction was concentrated in vacuo