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Diisopropylethylamine → N-(2-(4-(hydroxymethyl)piperidin-1-yl)ethyl)methanesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | N-(2-bromoethyl)methanesulfonamide | HCID 285330 | — |
| 反応物 | 4-Piperidinemethanol | HCID 420771 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | N-(2-(4-(hydroxymethyl)piperidin-1-yl)ethyl)methanesulfonamide | HCID 19962114 | 54.8% |
反応手順
4-Piperidine methanol (1.60 g) was dissolved in dry acetonitrile (40 ml), N,N-diisopropylethylamine (5 ml) was added, followed by N-(2-bromoethyl)methanesulphonamide (2.95 g) in acetonitrile (10 ml), and the resulting mixture heated at reflux for 2 h. The solvent was removed in vacuo to leave a gum. This was purified by FCC eluting with System A (75:8:1) to give the title compound (1.80 g) as a solid, m.p. 81°-82°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05618827 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-b799967ecb2b40aeb1be5ec9736eebe1 |
| 出典メモ | uspto-grants-1997_04 |