反应详情

4-Piperidine methanol (1.60 g) was dissolved in dry acetonitrile (40 ml), N,N-diisopropylethylamine (5 ml) was added, followed by N-(2-bromoethyl)methanesulphonamide (2.95 g) in acetonitrile (10 ml), and the resulting mixture heated at reflux for 2 h. The solvent was removed in vacuo to leave a gum. This was purified by FCC eluting with System A (75:8:1) to give the title compound (1.80 g) as a solid, m.p. 81°-82°.

1. temperaturethe resulting mixture heated
2. temperatureat reflux for 2 h
3. customThe solvent was removed in vacuo
4. customto leave a gum
5. customThis was purified by FCC
6. washeluting with System A (75:8:1)