Ethyl Acetate → 1-(2-(2-Methoxy-4-nitrophenoxy)ethyl)pyrrolidine

HRID 532433

反応式

HRID 532433 の反応式
C(=O)([O-])[O-].[K+].[K+].[N+:7]([C:10]1[CH:11]=[C:12]([OH:18])[C:13]([O:16][CH3:17])=[CH:14][CH:15]=1)([O-:9])=[O:8].Cl.ClC[CH2:22][N:23]1[CH2:27][CH2:26][CH2:25][CH2:24]1.[C:28](OCC)(=O)C>CN(C=O)C.O>[CH3:28][O:18][C:12]1[CH:11]=[C:10]([N+:7]([O-:9])=[O:8])[CH:15]=[CH:14][C:13]=1[O:16][CH2:17][CH2:22][N:23]1[CH2:27][CH2:26][CH2:25][CH2:24]1

参加物

7

反応物 4

HCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 694712-Methoxy-5-nitrophenolHCID 816681-(2-Chloroethyl)pyrrolidine hydrochloride

生成物 1

HCID 179893551-(2-(2-Methoxy-4-nitrophenoxy)ethyl)pyrrolidine

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

Potassium carbonate (3.3 g) was added to a solution of 4-nitroguaiacol (1.0 g) and 1-(2-chloroethyl)pyrrolidine hydrochloride (1.0 g) in DMF (20.0 mL), and the mixture was heated at 100° C. overnight. The reaction mixture was then mixed with ethyl acetate and water, and the organic phase was washed twice with water, dried over sodium sulfate and concentrated. The product with the molecular weight of 266.3 (C13H18N2O4) was obtained in this way; MS (ESI): 267 (M+H+).

後処理

  1. washthe organic phase was washed twice with water
  2. dry with materialdried over sodium sulfate
  3. concentrationconcentrated
  4. customThe product with the molecular weight of 266.3 (C13H18N2O4) was obtained in this way

出典と根拠

ORDレコード
ord-25ff1ee11c9f40fc841bf714f6d2c747
出典データセット
uspto-grants-2014_10
特許番号
US08853208B2

関連ノート

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