Sodium hydride → 7-bromo-4-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yloxy)-5-methyl-5H-pyrrolo[3,2-d]pyrimidine

1-(5-ethylpyrimidin-2-yl)piperidin-4-ol (93 mg) was added to DMF (5 mL), and cooled to 0° C. Then, NaH (27 mg) was added thereto, and stirred for 30 min. 7-bromo-4-chloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine (100 mg) was added thereto, and stirred at room temperature for 12 hours. The reaction mixture was extracted with ethyl acetate and distilled water, and the organic layer thus obtained was washed with water and a saline solution. Subsequently, the washed organic layer was dried over anhydrous sodium sulfate, and concentrated under reduced pressure to obtain the title compound.

1. stirringstirred at room temperature for 12 hours
2. extractionThe reaction mixture was extracted with ethyl acetate
3. distillationdistilled water
4. customthe organic layer thus obtained
5. washwas washed with water
6. dry with materialSubsequently, the washed organic layer was dried over anhydrous sodium sulfate
7. concentrationconcentrated under reduced pressure

ORDレコード

ord-c91c10788d8043fd9ac61cb1650968a8

出典データセット

uspto-grants-2014_10

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08853213B2