Triethylamine → 4-(1H-1,2,4-Triazol-1-yl)phenyl 1,1,1-trifluoromethanesulfonate

HRID 532500ノート

反応式

HRID 532500 の反応式
[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=2)[CH:5]=[N:4][CH:3]=[N:2]1.C(N(CC)CC)C.[O:20](S(C(F)(F)F)(=O)=O)[S:21]([C:24]([F:27])([F:26])[F:25])(=O)=[O:22]>ClCCl>[N:1]1([C:6]2[CH:7]=[CH:8][C:9]([O:12][S:21]([C:24]([F:27])([F:26])[F:25])(=[O:22])=[O:20])=[CH:10][CH:11]=2)[CH:5]=[N:4][CH:3]=[N:2]1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 67749Trifluoromethanesulfonic anhydrideHCID 1100644-(1,2,4-Triazol-1-yl)phenol

生成物 1

HCID 866131654-(1H-1,2,4-Triazol-1-yl)phenyl 1,1,1-trifluoromethanesulfonate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1.0 g of 4-[1,2,4]triazol-1-yl-phenol was dissolved in 10 ml of dichloromethane, and 1.72 ml of triethylamine was added thereto. 1.56 ml of Tf2O was added to the mixture and stirred for 5 hr. The reaction was terminated by using water, and the resulting mixture was extracted with dichloromethane, dried over anhydrous sodium sulfate, and concentrated under a reduced pressure to obtain the title compound.

後処理

  1. customThe reaction was terminated
  2. extractionthe resulting mixture was extracted with dichloromethane
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated under a reduced pressure

出典と根拠

ORDレコード
ord-0accd0b89165430a8f7a88ff3ae105a5
出典データセット
uspto-grants-2014_10
特許番号
US08853213B2

反応ノート

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