Sodium Hydroxide → 4-Ethoxycarbonyl-2-methylthiothiazole-5-carboxylic acid

HRID 5329

反応式

HRID 5329 の反応式
[OH-].[Na+].[CH3:3][S:4][C:5]1[S:6][C:7]([C:15]([O:17]CC)=[O:16])=[C:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:9]=1>O.C(O)C.O>[CH2:13]([O:12][C:10]([C:8]1[N:9]=[C:5]([S:4][CH3:3])[S:6][C:7]=1[C:15]([OH:17])=[O:16])=[O:11])[CH3:14]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 15009537Diethyl 2-methylthiothiazole-4,5-dicarboxylate

生成物 1

HCID 150095384-Ethoxycarbonyl-2-methylthiothiazole-5-carboxylic acid

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 19096565Water ethanol溶媒

実験手順

At room temperature, a solution of 1.10 g (27.5 mmol) of sodium hydroxide in 10 ml of water was added over a period of one hour to a solution of 7.00 g (25 mmol) of diethyl 2-methylthiothiazole-4,5-dicarboxylate in 100 ml of ethanol/water (2:1). The mixture was stirred for one hour, the solvent mixture was then removed under reduced pressure, the residue was taken up in 100 ml of water, the solution was extracted once with 50 ml of diethyl ether, and the aqueous phase was acidified with concentrated hydrochloric acid. The precipitated product was filtered off and dried.

後処理

  1. customthe solvent mixture was then removed under reduced pressure
  2. extractionthe solution was extracted once with 50 ml of diethyl ether
  3. filtrationThe precipitated product was filtered off
  4. customdried

出典と根拠

ORDレコード
ord-cac5b60f283041dda7c7abbd2044a9b6
出典データセット
uspto-grants-1993_09
特許番号
US05244867

関連ノート

読み込み中…