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Water → ethyl 2-chloro-4-(1-methyl-1H-indol-4-ylamino)pyrimidine-5-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | Ethyl 2,4-dichloropyrimidine-5-carboxylate | HCID 104020 | — |
| 反応物 | 1-methyl-1H-indol-4-amine | HCID 22170307 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | ethyl 2-chloro-4-(1-methyl-1H-indol-4-ylamino)pyrimidine-5-carboxylate | HCID 58014943 | — |
反応手順
To a solution of ethyl 2,4-dichloropyrimidine-5-carboxylate (328 mg, 1.48 mmol) and 1-methyl-1H-indol-4-amine (260 mg, 1.78 mmol) in CH3CN (6 mL) at room temperature, DIEA (0.4 mL, 2.22 mmol) was added. The mixture was stirred at room temperature for 24 h. Water (15 mL) was added to induce precipitation. The precipitate was collected, dried on vacuum to give ethyl 2-chloro-4-(1-methyl-1H-indol-4-ylamino)pyrimidine-5-carboxylate as a solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08853230B2 |
| 出典データセット | uspto-grants-2014_10 |
| ORD ID | ord-ef6c05deb3414e30b3b638c5d5d80c87 |
| 出典メモ | uspto-grants-2014_10 |