Oxalyl chloride → Cinnamoyl Chloride

HRID 53350

反応式

HRID 53350 の反応式
[C:1]([OH:11])(=O)/[CH:2]=[CH:3]/[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.C(Cl)(=O)C([Cl:15])=O>C1(C)C=CC=CC=1>[C:1]([Cl:15])(=[O:11])/[CH:2]=[CH:3]/[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 444539Cinnamic Acid

生成物 1

HCID 5354261Cinnamoyl Chloride収率 135.9%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
0 °C

実験手順

trans-Cinnamic acid (5 g, 33.7 mmol, Aldrich) was dissolved in toluene (100 mL), and the solution was cooled to 0° C. and flushed with N2. Anhydrous DMF (0.1 mL) was added, followed by oxalyl chloride (8.56 g, 5.88 mL, 67.4 mmol) dropwise over 8 minutes. The mixture was stirred at 0° C. for 1 hour and at room temperature for 1.5 hours. The solvent was removed under vacuum to give the title compound (7.63 g).

後処理

  1. customflushed with N2
  2. additionAnhydrous DMF (0.1 mL) was added
  3. customThe solvent was removed under vacuum

出典と根拠

ORDレコード
ord-5922897b2fd84ef282b4a00b663a2f4c
出典データセット
uspto-grants-1997_04
特許番号
US05618949

関連ノート

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