4-Bromophenol → Phenol, 4-(3-pyridinyl)-

HRID 5339

反応式

HRID 5339 の反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.C([Sn](CCCC)(CCCC)[C:14]1[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=1)CCC>O1CCOCC1.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[N:16]1[CH:17]=[CH:18][CH:19]=[C:14]([C:2]2[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=2)[CH:15]=1

参加物

5

反応物 2

HCID 78084-BromophenolHCID 34838483-(Tributylstannyl)pyridine

生成物 1

HCID 153040Phenol, 4-(3-pyridinyl)-収率 60%

試薬・触媒・溶媒 2

HCID 178418476HCID 178418476、化合物触媒HCID 312751,4-Dioxane溶媒

実験手順

26.8 g of 4-bromophenol was taken under protective gas in 1000 ml of dioxane, mixed with 90 g 3-tributylstannylpyridine [preparation according to litt.: Org. Magn. Resonance, 7 (1975), 610] and 11.1 g of bis-(triphenylphosphine)-palladium(II) chloride and refluxed for 15 hours. After concentration by evaporation in a vacuum and purification on silica gel, 15.92 g of the above compound is isolated.

後処理

  1. temperaturerefluxed for 15 hours
  2. concentrationAfter concentration
  3. customby evaporation
  4. customin a vacuum and purification on silica gel

出典と根拠

ORDレコード
ord-7844a06e09664a17934167953fba756b
出典データセット
uspto-grants-1993_09
特許番号
US05244886

関連ノート

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