Methyl 2-fluoro-3-nitrobenzoate → Methyl 3-amino-2-fluorobenzoate hydrochloride

HRID 534665ノート

反応式

HRID 534665 の反応式
[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-])=O)[C:5]=1[F:13].[ClH:15].CO>[Pd].CO>[ClH:15].[NH2:10][C:6]1[C:5]([F:13])=[C:4]([CH:9]=[CH:8][CH:7]=1)[C:3]([O:2][CH3:1])=[O:14]

参加物

5

反応物 2

HCID 13470961Methyl 2-fluoro-3-nitrobenzoateHCID 21893726Hydrochloride methanol

生成物 1

HCID 67167731Methyl 3-amino-2-fluorobenzoate hydrochloride収率 85%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

2-Fluoro-3-nitrobenzoic acid methyl ester (9.10 g, 0.046 mol), 10% hydrochloric acid/methanol (25 ml), methanol (60 ml), and 5% palladium/carbon (50% wet product) (2.7 g) were introduced, and the reaction mixture was hydrogenated at room temperature. After completion of the reaction, the catalyst was filtered away, and the filtrate was concentrated under reduced pressure. The concentration residue was washed with diisopropyl ether, as a result of which 8.01 g (yield: 85%) of the indicated compound was obtained.

後処理

  1. customwas hydrogenated at room temperature
  2. customAfter completion of the reaction
  3. filtrationthe catalyst was filtered away
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. washThe concentration residue was washed with diisopropyl ether

出典と根拠

ORDレコード
ord-4ca83f54d0934a93b6ccb7a2892b52c0
出典データセット
uspto-grants-2014_10
特許番号
US08853440B2

反応ノート

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