Dimethylacetamide → 4-Bromo-3,5-dimethyl-benzonitrile

温度

50 °C

Trifluoro-methanesulfonic acid 4-bromo-3,5-dimethyl-phenyl ester (79.8 g, 0.24 mol) and AcCN (500 mL) were added to a 3 necked, 2.0 L round bottom flask equipped with mechanical stirrer, nitrogen inlet adapter, heating mantle and thermocouple. To the resulting solution were then added Pd(PPh3)4 (27.7 g, 0.024 mol), CuI (9.2 g, 0.048 mol) and Zn(CN)2 (79.8 g, 0.24 mol). The resulting mixture was stirred for 45 minutes at 50° C., DMAc (150 mL) was added and the temperature was increased to 80-88° C. and the mixture aged at this temperature overnight. The resulting mixture was cooled to ambient temperature, diluted with EtOAc (200 mL), and filtered with STAND SUPER-CEL 815520. The SUPER-CEL cake was rinsed with EtOAc (200 mL×6). The EtOAc solutions were combined and quenched with a 4:1:4 mixture of saturated NH4Cl:concentrated NH4OH:H2O (240 mL:60 mL:240 mL). The layers were separated and the organic layer was rinsed once with water (500 mL) and once with brine (500 mL), then concentrated to dryness in vacuo to yield a red thick oil. The title compound was crystallized from EtOAc (135 mL) and heptanes (500 mL) to yield white-yellowish crystal.

1. custom2.0 L round bottom flask equipped with mechanical stirrer, nitrogen inlet adapter
2. temperatureheating mantle
3. temperaturethe temperature was increased to 80-88° C.
4. customaged at this temperature overnight
5. temperatureThe resulting mixture was cooled to ambient temperature
6. filtrationfiltered with STAND SUPER-CEL 815520
7. washThe SUPER-CEL cake was rinsed with EtOAc (200 mL×6)
8. customquenched with a 4:1:4 mixture of saturated NH4Cl
9. customThe layers were separated
10. washthe organic layer was rinsed once with water (500 mL) and once with brine (500 mL)
11. concentrationconcentrated to dryness in vacuo
12. customto yield a red thick oil
13. customThe title compound was crystallized from EtOAc (135 mL) and heptanes (500 mL)
14. customto yield white-yellowish crystal

ORDレコード

ord-9e466c1e7f234f948cfcfcd83d98e85e

出典データセット

uspto-grants-2014_10

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08853445B2