Thionyl Chloride → 6-(3-Fluorophenyl)-3-pyridinecarbonyl chloride

HRID 534742ノート

反応式

HRID 534742 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[CH:12][C:11]([C:14]([OH:16])=O)=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.S(Cl)([Cl:19])=O>O1CCOCC1>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[CH:12][C:11]([C:14]([Cl:19])=[O:16])=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 247299726-(3-Fluorophenyl)nicotinic acid

生成物 1

HCID 866181106-(3-Fluorophenyl)-3-pyridinecarbonyl chloride収率 99.3%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

6-(3-Fluorophenyl)-3-pyridinecarboxylic acid (82 mg, 0.376 mmol) was stirred in dioxane (4 mL) and thionyl chloride (0.137 mL, 1.88 mmol) added dropwise. The reaction mixture was heated at reflux for 40 min then concentrated in vacuo to give 6-(3-fluorophenyl)-3-pyridinecarbonyl chloride as a white solid (0.088 g) which was used directly in step 2.

後処理

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 40 min
  3. concentrationthen concentrated in vacuo

出典と根拠

ORDレコード
ord-c4505d7185bb43ecbb62bf048c82df5f
出典データセット
uspto-grants-2014_10
特許番号
US08853218B2

反応ノート

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