Hydrochloric Acid → 2-Tert-butyl-4-chloroaniline
反応式
[C:1]([C:5]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:6]=1[NH:12]C(=O)C)([CH3:4])([CH3:3])[CH3:2].Cl.[OH-].[Na+]>CCO>[C:1]([C:5]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:6]=1[NH2:12])([CH3:4])([CH3:2])[CH3:3]参加物
5
反応条件
- 温度
- 110 °C
実験手順
A mixture of N-(2-tert-butyl-4-chlorophenyl)acetamide (Reference Example 18, 4.78 g, 21.2 mmol), concentrated HCl (50 mL) and EtOH (10 mL) was stirred at 110° C. for 5 h. After cooling, the reaction mixture was basified with 8 M NaOH under ice-cooling. The mixture was extracted with ethyl acetate and the organic layer was washed with water, and saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the title compound (4.29 g) as a colorless oil.
後処理
- temperatureAfter cooling
- temperaturecooling
- extractionThe mixture was extracted with ethyl acetate
- washthe organic layer was washed with water, and saturated brine
- dry with materialdried over anhydrous magnesium sulfate
- filtrationfiltered
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-05696247048843038986c648ec9e7acd
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08853215B2
反応ノート
読み込み中…