2-Chloronicotinoyl chloride → N-(2-Bromo-6-methoxy-3-pyridinyl)-2-chloro-3-pyridinecarboxamide

HRID 53523

反応式

HRID 53523 の反応式
[NH2:1][C:2]1[C:3]([Br:10])=[N:4][C:5]([O:8][CH3:9])=[CH:6][CH:7]=1.[Cl:11][C:12]1[N:20]=[CH:19][CH:18]=[CH:17][C:13]=1[C:14](Cl)=[O:15]>C(Cl)Cl.N1C=CC=CC=1>[Br:10][C:3]1[C:2]([NH:1][C:14]([C:13]2[C:12]([Cl:11])=[N:20][CH:19]=[CH:18][CH:17]=2)=[O:15])=[CH:7][CH:6]=[C:5]([O:8][CH3:9])[N:4]=1

参加物

5

反応物 2

HCID 27745412-Chloronicotinoyl chlorideHCID 152093242-Bromo-6-methoxypyridin-3-amine

生成物 1

HCID 10617311N-(2-Bromo-6-methoxy-3-pyridinyl)-2-chloro-3-pyridinecarboxamide収率 95.7%

試薬・触媒・溶媒 2

HCID 1049Pyridine溶媒HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of 3-amino-2-bromo-6-methoxypyridine (2.7 g) in methylene chloride (20 ml) and pyridine (1 ml) was added 2-chloronicotinoyl chloride (2.2 g), and the resulting mixture was stirred 20 min. The mixture was then diluted with methylene chloride (100 ml), washed with water (100 ml), dried (anhydrous magnesium sulfate), and concentrated. The semisolid residue was saturated with hexane, filtered, and dried to give 4.1 g of product suitable for use in the next reaction.

後処理

  1. washwashed with water (100 ml)
  2. dry with materialdried (anhydrous magnesium sulfate)
  3. concentrationconcentrated
  4. filtrationfiltered
  5. customdried

出典と根拠

ORDレコード
ord-ab68f65f49af453c8471dd3e1e060b1a
出典データセット
uspto-grants-1997_04
特許番号
US05620974

関連ノート

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