Sodium Carbonate → 5-Bromo-2-chloro-6-(N,N-dimethylamino)-4-methylpyridine-3-carboxamide

HRID 53542ノート

反応式

HRID 53542 の反応式
[Br:1][C:2]1[C:3]([CH3:14])=[C:4]([C:12]#[N:13])[C:5]([Cl:11])=[N:6][C:7]=1[N:8]([CH3:10])[CH3:9].C(=O)([O-])[O-:16].[Na+].[Na+]>S(=O)(=O)(O)O.O>[Br:1][C:2]1[C:3]([CH3:14])=[C:4]([C:12]([NH2:13])=[O:16])[C:5]([Cl:11])=[N:6][C:7]=1[N:8]([CH3:9])[CH3:10]

参加物

5

反応物 2

HCID 10340Sodium CarbonateHCID 199600285-bromo-2-chloro-3-cyano-6-(N,N-dimethylamino)-4-methylpyridine

生成物 1

HCID 199600805-Bromo-2-chloro-6-(N,N-dimethylamino)-4-methylpyridine-3-carboxamide

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1118Sulfuric Acid溶媒

実験手順

A solution of 5-bromo-2-chloro-3-cyano-6-(N,N-dimethylamino)-4-methylpyridine (1.3 g) in concentrated sulfuric acid (3 mL) was heated at 120° C. for 10 minutes. The mixture was cooled, diluted with water (50 mL), and neutralized with saturated sodium carbonate. After extraction with methylene chloride, evaporation of the organic phase gave 1.37 g of the title compound, suitable for use in the next reaction.

後処理

  1. temperatureThe mixture was cooled
  2. extractionAfter extraction
  3. customwith methylene chloride, evaporation of the organic phase

出典と根拠

ORDレコード
ord-c19a768d91a2451cbbbb8117fdd94cca
出典データセット
uspto-grants-1997_04
特許番号
US05620974

反応ノート

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