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Water → Methyl 2-amino-5-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | 2-Amino-5-[(1-Methoxy-2-Methylindolizin-3-Yl)carbonyl]benzoic Acid | HCID 11347895 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Methyl 2-amino-5-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]benzoate | HCID 66653263 | — |
反応手順
1.51 ml (24.26 mmol) of methyl iodide are added, under an inert atmosphere at ambient temperature, to 8 g (23.1 mmol) of the sodium salt of 2-amino-5-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]benzoic acid (described in WO 03/084956) in 130 ml of DMF. After stirring for 1 hour, water is added. The precipitate formed is filtered off, rinsed with water, and then dried under reduced pressure at 50° C. overnight. 7.17 g of a yellow solid are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08859544B2 |
| 出典データセット | uspto-grants-2014_10 |
| ORD ID | ord-946809f534a0476a88d787154b73908a |
| 出典メモ | uspto-grants-2014_10 |