Piperidin-3-ylmethanol → 5,11-Dihydro-11-ethyl-2-[3-(hydroxymethyl)piperidin-1-yl]-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
反応式
Cl[C:2]1[CH:3]=[C:4]([CH3:20])[C:5]2[NH:6][C:7](=[O:19])[C:8]3[CH:18]=[CH:17][CH:16]=[N:15][C:9]=3[N:10]([CH2:13][CH3:14])[C:11]=2[N:12]=1.[NH:21]1[CH2:26][CH2:25][CH2:24][CH:23]([CH2:27][OH:28])[CH2:22]1>>[CH2:13]([N:10]1[C:9]2[N:15]=[CH:16][CH:17]=[CH:18][C:8]=2[C:7](=[O:19])[NH:6][C:5]2[C:4]([CH3:20])=[CH:3][C:2]([N:21]3[CH2:26][CH2:25][CH2:24][CH:23]([CH2:27][OH:28])[CH2:22]3)=[N:12][C:11]1=2)[CH3:14]参加物
3
実験手順
The title compound, m.p. 194°-197° C., was synthesized from 2-chloro-5,11-dihydro-11l-ethyl-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one and 3-piperidinemethanol using procedures analogous to those described above, except that the mixture was heated at 170°-180° C. for 2.5 hrs, and the product was crystallized from ethyl acetate.
出典と根拠
- ORDレコード
- ord-86d277589fbe4f28b104e3eb723a4307
- 出典データセット
- uspto-grants-1997_04