Sodium borohydride → 2-(6-Methoxypyridin-2-yl)ethan-1-ol

HRID 535666

反応式

HRID 535666 の反応式
[BH4-].[Na+].[CH3:3][O:4][C:5]1[N:10]=[C:9]([CH2:11][C:12](OCC)=[O:13])[CH:8]=[CH:7][CH:6]=1>C(O)C>[CH3:3][O:4][C:5]1[N:10]=[C:9]([CH2:11][CH2:12][OH:13])[CH:8]=[CH:7][CH:6]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 55263200Ethyl 2-(6-methoxypyridin-2-YL)acetate

生成物 1

HCID 153198712-(6-Methoxypyridin-2-yl)ethan-1-ol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Sodium borohydride (1.3 g, 34.8 mmol) was added to a solution of ethyl 2-(6-methoxypyridin-2-yl)acetate (0.68 g, 3.48 mmol) in ethanol (20 mL). The resulting solution was stirred at room temperature over night. The solvent was removed in vacuo. Ethyl acetate and saturated NaHCO3 solution were added. The organic layer was separated and the aqueous layer was extracted with ethyl acetate. The combined organic layers were dried (Na2SO4) and concentrated to give the product. Yield: 0.23 g (44%).

後処理

  1. customThe solvent was removed in vacuo
  2. additionEthyl acetate and saturated NaHCO3 solution were added
  3. customThe organic layer was separated
  4. extractionthe aqueous layer was extracted with ethyl acetate
  5. dry with materialThe combined organic layers were dried (Na2SO4)
  6. concentrationconcentrated
  7. customto give the product

出典と根拠

ORDレコード
ord-6580ffdd5e6b405c92aec2bef7c66149
出典データセット
uspto-grants-2014_10
特許番号
US08859534B2

関連ノート

読み込み中…