反応式
Cl.C(O[C:5]([C:7]1[NH:8][CH:9]=[CH:10][C:11]=1[NH2:12])=[O:6])C.[F:13][C:14]1[CH:15]=[C:16]2[C:20](=[CH:21][CH:22]=1)[NH:19][CH:18]=[C:17]2[CH:23]=O.[BH3-]C#N.[Na+].CCN(CC)CC.C([N:44]=[C:45]=[S:46])(=O)C1C=CC=CC=1>CO>[F:13][C:14]1[CH:15]=[C:16]2[C:20](=[CH:21][CH:22]=1)[NH:19][CH:18]=[C:17]2[CH2:23][N:12]1[C:11]2[CH:10]=[CH:9][NH:8][C:7]=2[C:5](=[O:6])[NH:44][C:45]1=[S:46]参加物
反応物 5
生成物 1
試薬・触媒・溶媒 1
実験手順
3-Amino-1H-pyrrole-2-carboxylic acid ethyl ester hydrochloride (0.10 g, 0.52 mmol) was dissolved in methanol (4 mL) and 5-fluoro-1H-indole-3-carboxaldehyde (0.10 g, 0.63 mmol), NaCNBH3 (0.033 g, 0.52 mmol) and Et3N (0.073 g, 0.52 mmol) were added. The resulting mixture was stirred at r.t. overnight. Additional NaCNBH3 (0.01 g) was added and the mixture was heated at 50° C. for 5 h. The reaction mixture was cooled to r.t. and concentrated in vacuo. The crude intermediate was dissolved in CH2Cl2 (3 mL) and methanol (1 mL). Benzoyl isothiocyanate (0.078 mL, 0.58 mmol) was added and after stirring at r.t. for 1 h the mixture was concentrated in vacuo. The residue was dissolved in ammonia (7N in methanol, 3 mL) and heated at 80° C. for 2 h. The solvent was removed in vacuo and after purification by preparative HPLC, the title compound (0.035 g, 21%) was obtained as a solid.
後処理
- temperaturethe mixture was heated at 50° C. for 5 h
- temperatureThe reaction mixture was cooled to r.t.
- concentrationconcentrated in vacuo
- dissolutionThe crude intermediate was dissolved in CH2Cl2 (3 mL)
- stirringafter stirring at r.t. for 1 h the mixture
- concentrationwas concentrated in vacuo
- dissolutionThe residue was dissolved in ammonia (7N in methanol, 3 mL)
- temperatureheated at 80° C. for 2 h
- customThe solvent was removed in vacuo
- customafter purification by preparative HPLC
出典と根拠
- ORDレコード
- ord-a04e86668dd74bb18d635926ec5be031
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08859568B2
関連ノート
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