Methyl iodide → 2-Amino-4-(3,5-diacetylphenyl)amino-1,6-dimethylpyrimidinium iodide

HRID 53611

反応式

HRID 53611 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:14]=[C:13]([C:15](=[O:17])[CH3:16])[CH:12]=[C:11]([C:18](=[O:20])[CH3:19])[CH:10]=2)[CH:5]=[C:4]([CH3:21])[N:3]=1.[CH3:22][I:23]>C(#N)C.O1CCCC1>[I-:23].[NH2:1][C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:10]=[C:11]([C:18](=[O:20])[CH3:19])[CH:12]=[C:13]([C:15](=[O:17])[CH3:16])[CH:14]=2)[CH:5]=[C:4]([CH3:21])[N+:3]=1[CH3:22]

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 133109Cni H1194

生成物 1

HCID 98453522-Amino-4-(3,5-diacetylphenyl)amino-1,6-dimethylpyrimidinium iodide

試薬・触媒・溶媒 1

HCID 22177404Acetonitrile tetrahydrofuran溶媒

実験手順

Compound No. 2, FIG. 1A: A suspension of Compound No. 11 (2-amino-4-(3,5-diacetylphenyl)amino-6-methylpyrimidine) (0.284 g), was suspended in 1:1 acetonitrile-tetrahydrofuran was treated with methyl iodide (2 mL) and heated at 40°-45° C. under a reflux condenser for 18 hr. Cooling and filtration gave 0.35 g of 2-amino-4-(3,5-diacetylphenyl)amino-1,6-dimethylpyrimidinium iodide, mp 292° C.

後処理

  1. addition2, FIG. 1A: A suspension of Compound No
  2. temperatureheated at 40°-45° C. under a reflux condenser for 18 hr
  3. temperatureCooling
  4. filtrationfiltration

出典と根拠

ORDレコード
ord-a05d8b8e55a9435dae8e8ee9d12176d5
出典データセット
uspto-grants-1997_04
特許番号
US05620983

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