反応式
[CH3:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][CH:5]=[C:4]([N:11]2[CH2:15][CH2:14][C@@H:13]([N:16]3[CH2:20][CH2:19][CH2:18][C@@H:17]3[CH3:21])[CH2:12]2)[N:3]=1>C(O)C.[Pd]>[CH3:1][C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[C:4]([N:11]2[CH2:15][CH2:14][C@@H:13]([N:16]3[CH2:20][CH2:19][CH2:18][C@@H:17]3[CH3:21])[CH2:12]2)[N:3]=1参加物
4
実験手順
A mixture of 2-methyl-6-[(3R)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]-3-nitro-pyridine (2.0 g, 6.89 mmol) and 10% Pd/C (200 mg) in ethanol (40 mL) was shaken on a parr shaker under 50 psi H2 for 18 h. The reaction mixture was filtered through a celite pad and concentrated to afford a dark red oil which was then purified by flash column chromatography (10% MeOH/CH2Cl2) to afford 580 mg (32% yield) of the title compound as an oil.
後処理
- filtrationThe reaction mixture was filtered through a celite pad
- concentrationconcentrated
- customto afford a dark red oil which
- customwas then purified by flash column chromatography (10% MeOH/CH2Cl2)
出典と根拠
- ORDレコード
- ord-af3e9df8dc504b70ab1aff2832d8e575
- 出典データセット
- uspto-grants-2014_10
- 特許番号
- US08859588B2
関連ノート
読み込み中…