Water → 2,5-Dichloro-N-(5-ethyl-1H-pyrazol-3-yl)pyrimidin-4-amine

HRID 536335

反応式

HRID 536335 の反応式
[CH2:1]([C:3]1[NH:7][N:6]=[C:5]([NH2:8])[CH:4]=1)[CH3:2].[Cl:9][C:10]1[N:15]=[C:14](Cl)[C:13]([Cl:17])=[CH:12][N:11]=1.C([O-])([O-])=O.[Na+].[Na+].O>C(O)(C)C>[Cl:9][C:10]1[N:15]=[C:14]([NH:8][C:5]2[CH:4]=[C:3]([CH2:1][CH3:2])[NH:7][N:6]=2)[C:13]([Cl:17])=[CH:12][N:11]=1

参加物

6

反応物 4

HCID 962WaterHCID 10340Sodium CarbonateHCID 2372592,4,5-TrichloropyrimidineHCID 219910953-ethyl-1H-pyrazol-5-amine

生成物 1

HCID 582551482,5-Dichloro-N-(5-ethyl-1H-pyrazol-3-yl)pyrimidin-4-amine

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

A mixture of 5-ethyl-1H-pyrazol-3-amine (1.00 g, 6.77 mmol), 2,4,5-trichloropyrimidine (1.24 g, 6.77 mmol) and Na2CO3 (1.79 g, 16.9 mmol) in iso-propanol (15 mL) was stirred in a sealed vial at rt for two days. Water (10 mL) was added. The solid was collected by filtration, washed with water (10 mL) and dried to give 2,5-Dichloro-N-(5-ethyl-1H-pyrazol-3-yl)pyrimidin-4-amine as a light yellow solid; ESMS m/z 258.0 (M+H+).

後処理

  1. filtrationThe solid was collected by filtration
  2. washwashed with water (10 mL)
  3. customdried

出典と根拠

ORDレコード
ord-5ebc5cc038894190ba0606688373b6e6
出典データセット
uspto-grants-2014_10
特許番号
US08859574B2

関連ノート

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