Methanol → 4-amino-2,3-dihydro-1H-inden-2-ol

HRID 536446

反応式

HRID 536446 の反応式
C([O:4][CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[NH2:14])[CH2:6]1)(=O)C.CO.C(=O)([O-])[O-].[K+].[K+]>CC(O)C>[NH2:14][C:11]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:12]=1[CH2:13][CH:5]([OH:4])[CH2:6]2

参加物

5

反応物 3

HCID 887MethanolHCID 11430Potassium CarbonateHCID 132395844-amino-2,3-dihydro-1H-inden-2-yl acetate

生成物 1

HCID 545954264-amino-2,3-dihydro-1H-inden-2-ol収率 99%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

A slurry of 4-amino-2,3-dihydro-1H-inden-2-yl acetate (12.6 g, 65.9 mmol; prepared according to US2003109700), MeOH (63 mL), and potassium carbonate (13.7 g, 99.0 mmol) was stirred at ambient temperature for 15 minutes. The reaction mixture was diluted with IPA (630 mL), passed through a plug of silica gel, washed with IPA (100 mL), and concentrated to give the title compound (9.70 g, 65.0 mmol, 99%). MS (DCI) m/z 267 (M+NH4)+.

後処理

  1. washwashed with IPA (100 mL)
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-228c365d383e4ceba0442cb320284762
出典データセット
uspto-grants-2014_10
特許番号
US08859584B2

関連ノート

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