Trifluoroacetic acid → 3-Chloro-4-{[3-(4-chlorophenyl)-4-cyclopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}benzoic acid
反応式
C([O:5][C:6](=[O:31])[C:7]1[CH:12]=[CH:11][C:10]([CH2:13][N:14]2[C:18](=[O:19])[N:17]([CH:20]3[CH2:22][CH2:21]3)[C:16]([C:23]3[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=3)=[N:15]2)=[C:9]([Cl:30])[CH:8]=1)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[Cl:30][C:9]1[CH:8]=[C:7]([CH:12]=[CH:11][C:10]=1[CH2:13][N:14]1[C:18](=[O:19])[N:17]([CH:20]2[CH2:22][CH2:21]2)[C:16]([C:23]2[CH:24]=[CH:25][C:26]([Cl:29])=[CH:27][CH:28]=2)=[N:15]1)[C:6]([OH:31])=[O:5]参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
An amount of 1.38 g (3.00 mmol) of the compound from Example 26A was dissolved in 10 ml of dichloromethane and admixed at RT with 3.0 ml (39 mmol) of trifluoroacetic acid and stirred at RT for 72 h. The mixture was concentrated under reduced pressure and admixed with 10 ml of toluene and concentrated again. This procedure was repeated a further two times. The residue which remained was freed from remnants of solvent under a high vacuum. This gave 1.27 g (63% of theory) of the target compound with a purity of 60%.