Hydrochloric Acid → 5-Methoxy-3-methoxycarbonylmethyl-indan-1-yl-ammonium chloride

HRID 536636ノート

反応式

HRID 536636 の反応式
[CH3:1][O:2][C:3](=[O:18])[CH2:4][CH:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:14][CH3:15])[CH:12]=2)[C:7](=[N:16]O)[CH2:6]1.[ClH:19]>[Pd].CO>[Cl-:19].[CH3:15][O:14][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[CH:7]([NH3+:16])[CH2:6][CH:5]2[CH2:4][C:3]([O:2][CH3:1])=[O:18]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 86650493(3-Hydroxyimino-6-methoxy-indan-1-yl)-acetic acid methyl ester

生成物 1

HCID 866562075-Methoxy-3-methoxycarbonylmethyl-indan-1-yl-ammonium chloride

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of 10% palladium on carbon (3.0 g), (3-hydroxyimino-6-methoxy-indan-1-yl)-acetic acid methyl ester (12.5 g), and concentrated hydrochloric acid (4.7 mL) in methanol (150 mL) is stirred under hydrogen atmosphere at room temperature overnight. The mixture is filtered and the filtrate is concentrated under reduced pressure. The residue is azeotropically dried using toluene and washed with diisopropylether to give the product as a white solid after drying at 50° C.

後処理

  1. filtrationThe mixture is filtered
  2. concentrationthe filtrate is concentrated under reduced pressure
  3. customThe residue is azeotropically dried
  4. washwashed with diisopropylether

出典と根拠

ORDレコード
ord-8c65e05a468e4c91a5f8a0a309f50f68
出典データセット
uspto-grants-2014_10
特許番号
US08859580B2

反応ノート

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