2,4-Dimethoxyphenyl isocyanate → 1-(2,4-Dimethoxyphenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-urea

HRID 536793

反応式

HRID 536793 の反応式
[N:1]1([C:7]2[N:12]=[C:11]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)[N:10]=[C:9]([C:19]3[CH:25]=[CH:24][C:22]([NH2:23])=[CH:21][CH:20]=3)[N:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH3:26][O:27][C:28]1[CH:33]=[C:32]([O:34][CH3:35])[CH:31]=[CH:30][C:29]=1[N:36]=[C:37]=[O:38]>>[CH3:26][O:27][C:28]1[CH:33]=[C:32]([O:34][CH3:35])[CH:31]=[CH:30][C:29]=1[NH:36][C:37]([NH:23][C:22]1[CH:24]=[CH:25][C:19]([C:9]2[N:8]=[C:7]([N:1]3[CH2:2][CH2:3][O:4][CH2:5][CH2:6]3)[N:12]=[C:11]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)[N:10]=2)=[CH:20][CH:21]=1)=[O:38]

参加物

3

反応物 2

HCID 6016372,4-Dimethoxyphenyl isocyanateHCID 453790874-(4,6-Dimorpholino-1,3,5-triazin-2-yl)aniline

生成物 1

HCID 445142021-(2,4-Dimethoxyphenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-urea

実験手順

Starting from 4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)aniline (0.140 g 0.40 mmoles) and 2,4-dimethoxyphenyl isocyanate (131 mg, 0.73 mmoles), the title compound was isolated as a white solid. Yield; 76 mg (36%); (M+H)=522.4

出典と根拠

ORDレコード
ord-4e48c6ae3cef467082dcd56c0689dc3d
出典データセット
uspto-grants-2014_10
特許番号
US08859542B2

関連ノート

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