Hydrochloric Acid → 1H-Indazole-3-carboxylic acid, 1-methyl-
反応式
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]([O:13]C)=[O:12])=[N:3]1.[OH-].[Na+].Cl>CO.O>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]([OH:13])=[O:12])=[N:3]1参加物
6
実験手順
A solution of 1-methylindazole-3-carboxylic acid, methyl ester (1.00 g, 0.0053 mol) was stirred in a mixture of methanol (10 mL)/2N NaOH solution (120 mL) at reflux temperature for 2 hours. After cooling, the mixture was diluted with water (100 mL) and acidified with 6N HCl solution. The white solid that formed was collected by filtration and dried under ambient conditions for 6 days to give 0.86 g (92% yield) of the product; mp 215°-216° C.
後処理
- temperatureat reflux temperature for 2 hours
- temperatureAfter cooling
- customThe white solid that formed
- filtrationwas collected by filtration
- customdried under ambient conditions for 6 days
出典と根拠
- ORDレコード
- ord-76e193244c0648009545e2db9839eabd
- 出典データセット
- uspto-grants-1993_09
- 特許番号
- US05244907
反応ノート
読み込み中…