Trifluoroacetic acid → HCID 178474095、化合物

HRID 537049ノート

反応式

HRID 537049 の反応式
C(O)(C(F)(F)F)=O.[Cl:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[O:19][C:18]([C:20]2[CH:25]=[CH:24][C:23]([NH:26][C:27](=[O:29])[CH3:28])=[CH:22][CH:21]=2)=[N:17][C:16]=1[C:30]1[N:34](COCC[Si](C)(C)C)[CH:33]=[N:32][N:31]=1>C(Cl)Cl>[Cl:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[O:19][C:18]([C:20]2[CH:21]=[CH:22][C:23]([NH:26][C:27](=[O:29])[CH3:28])=[CH:24][CH:25]=2)=[N:17][C:16]=1[C:30]1[N:34]=[CH:33][NH:32][N:31]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 66749648N-{4-[5-(2-chlorophenyl)-4-(4-{[2-(trimethylsilyl)ethoxy]methyl}-4H-1,2,4-triazol-3-yl)-1,3-oxazol-2-yl]phenyl}acetamide

生成物 1

HCID 178474095HCID 178474095、化合物収率 34.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

TFA (0.6 mL) was added to a solution of N-{4-[5-(2-chlorophenyl)-4-(4-{[2-(trimethylsilyl)ethoxy]methyl}-4H-1,2,4-triazol-3-yl)-1,3-oxazol-2-yl]phenyl}acetamide (0.10 g, 0.20 mmol) in DCM (3 mL). The reaction mixture was allowed to stir at rt overnight and then concentrated. The residue was purified by column chromatography to give N-{4-[5-(2-chlorophenyl)-4-(1H-1,2,4-triazol-3-yl)-1,3-oxazol-2-yl]phenyl}acetamide (Compound I-8) (0.026 g, 32%). LCMS (FA): m/z=380 (M+H).

後処理

  1. concentrationconcentrated
  2. customThe residue was purified by column chromatography

出典と根拠

ORDレコード
ord-fa0f5e72f67a4481a9c2259290808180
出典データセット
uspto-grants-2014_10
特許番号
US08859768B2

反応ノート

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