Oxalyl chloride → 3,3-Dimethylcyclobutane-1-carbonyl chloride

HRID 537460

反応式

HRID 537460 の反応式
[CH3:1][C:2]1([CH3:9])[CH2:5][CH:4]([C:6](O)=[O:7])[CH2:3]1.C(Cl)(=O)C([Cl:13])=O>ClCCl.CN(C)C=O>[CH3:1][C:2]1([CH3:9])[CH2:5][CH:4]([C:6]([Cl:13])=[O:7])[CH2:3]1

参加物

5

反応物 2

HCID 65578Oxalyl chlorideHCID 2151063,3-Dimethylcyclobutanecarboxylic acid

生成物 1

HCID 205352373,3-Dimethylcyclobutane-1-carbonyl chloride収率 100%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒

実験手順

To a 0° C. solution of 3,3-dimethylcyclobutanecarboxylic acid (1.35 g, 10.5 mmol) in dichloromethane (10 mL) was slowly added oxalyl chloride (4.01 g, 31.6 mmol) and 1 drop of N,N-dimethylformamide. The reaction was warmed to room temperature and stirred for 2 hours. The reaction was concentrated in vacuo to give crude 3,3-dimethylcyclobutanecarbonylchloride (1.54 g) as a yellow oil.

後処理

  1. customTo a 0° C.
  2. concentrationThe reaction was concentrated in vacuo

出典と根拠

ORDレコード
ord-f6fe8d442e40482e9aa1047922ee3ebe
出典データセット
uspto-grants-2014_10
特許番号
US08859591B2

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