Oxalyl chloride → 3,3-Difluorocyclobutanecarbonyl chloride

HRID 537487ノート

反応式

HRID 537487 の反応式
[F:1][C:2]1([F:9])[CH2:5][CH:4]([C:6](O)=[O:7])[CH2:3]1.C(Cl)(=O)C([Cl:13])=O>ClCCl>[F:1][C:2]1([F:9])[CH2:5][CH:4]([C:6]([Cl:13])=[O:7])[CH2:3]1

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 137777893,3-Difluorocyclobutane-1-carboxylic acid

生成物 1

HCID 838550033,3-Difluorocyclobutanecarbonyl chloride収率 50%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

3,3-Difluorocyclobutanecarboxylic acid (Parkway Scientific, New York, N.Y., USA) (531 mg, 3.90 mmol) was dissolved in dichloromethane (3.00 mL) and oxalyl chloride (1.02 mL, 11.7 mmol) was added. The solution was stirred at room temperature for 4 h before concentrating in vacuo to provide 3,3-difluorocyclobutanecarbonyl chloride (ca. 50% pure), which was carried on without purification.

後処理

  1. concentrationbefore concentrating in vacuo

出典と根拠

ORDレコード
ord-8f0abb41d77c4158a9788c9c01380702
出典データセット
uspto-grants-2014_10
特許番号
US08859591B2

反応ノート

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