Water → HCID 178487289、化合物

HRID 538080ノート

反応式

HRID 538080 の反応式
FC(F)(F)C(O)=O.C(OC([N:15]1[CH2:20][CH2:19][N:18]([C:21]([C@H:23]2[CH2:28][CH2:27][C@H:26]([CH2:29][N:30]3[C:34]4[CH:35]=[C:36]([O:39][CH3:40])[CH:37]=[CH:38][C:33]=4[N:32]([CH3:41])[C:31]3=[O:42])[CH2:25][CH2:24]2)=[O:22])[CH2:17][CH2:16]1)=O)(C)(C)C.O>C(Cl)Cl>[CH3:40][O:39][C:36]1[CH:37]=[CH:38][C:33]2[N:32]([CH3:41])[C:31](=[O:42])[N:30]([CH2:29][C@H:26]3[CH2:27][CH2:28][C@H:23]([C:21]([N:18]4[CH2:17][CH2:16][NH:15][CH2:20][CH2:19]4)=[O:22])[CH2:24][CH2:25]3)[C:34]=2[CH:35]=1

参加物

5

反応物 3

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 178487291HCID 178487291、化合物

生成物 1

HCID 178487289HCID 178487289、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Trifluoro acetic acid (8 ml) was added to a solution of trans-4-[4-(6-Methoxy-3-methyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-cyclohexanecarbonyl]-piperazine-1-carboxylic acid tert-butyl ester in DCM (19 ml). The solution was stirred at room temperature overnight and then 10 ml of water were added. The mixture was concentrated under reduced pressure and DCM (20 ml) were added. The organic solution was washed with a saturated solution of NaHCO3 (2×20 ml), dried over Na2SO4, filtered and the solvent evaporated to give the titled compound

後処理

  1. concentrationThe mixture was concentrated under reduced pressure and DCM (20 ml)
  2. additionwere added
  3. washThe organic solution was washed with a saturated solution of NaHCO3 (2×20 ml)
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. customthe solvent evaporated

出典と根拠

ORDレコード
ord-cad873a1b0604ff5bec90fe1d7ef3a79
出典データセット
uspto-grants-2014_10
特許番号
US08865704B2

反応ノート

読み込み中…