Bromomethylcyclopropane → 1-Cyclopropylmethylcytosine

反応式

N1C=CC(N)=NC1=O.BrCC1CC1.[NH2:14][C:15]1[CH:20]=[CH:19][N:18]([CH2:21][C:22]2[CH:27]=[CH:26]C=CC=2)[C:17](=[O:28])[N:16]=1>>[NH2:14][C:15]1[CH:20]=[CH:19][N:18]([CH2:21][CH:22]2[CH2:27][CH2:26]2)[C:17](=[O:28])[N:16]=1

参加物

反応物 3

HCID 81503Bromomethylcyclopropane

HCID 3085814-Amino-1-benzylpyrimidin-2(1H)-one

HCID 178418229Cytosine

生成物 1

HCID 214443201-Cyclopropylmethylcytosine

実験手順

4-Amino-1-cyclopropylmethyl-1H-pyrimidin-2-one was prepared from cytosine and (bromomethyl)cyclopropane using the methods described above for the preparation of 4-amino-1-benzyl-1H-pyrimidin-2-one.

出典と根拠

ORDレコード: ord-04e04d6499cb496d9cb2bef4d74f79e7
出典データセット: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08865725B2

反応ノート

読み込み中…