Hexane → 2,6-Di-tert-butyl-4-(2-nitrostyryl)phenol

HRID 53852

反応式

HRID 53852 の反応式
[C:1]([C:5]1[CH:6]=[C:7]([CH:10]=[C:11]([C:14]([CH3:17])([CH3:16])[CH3:15])[C:12]=1[OH:13])[CH:8]=O)([CH3:4])([CH3:3])[CH3:2].[N+:18]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[CH2:27]C(O)=O)([O-:20])=[O:19].N1CCCCC1.CCCCCC>C1(C)C(C)=CC=CC=1>[C:1]([C:5]1[CH:6]=[C:7]([CH:8]=[CH:27][C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[N+:18]([O-:20])=[O:19])[CH:10]=[C:11]([C:14]([CH3:17])([CH3:16])[CH3:15])[C:12]=1[OH:13])([CH3:4])([CH3:3])[CH3:2]

参加物

6

反応物 4

HCID 8058HexaneHCID 8082PiperidineHCID 732193,5-Di-tert-butyl-4-hydroxybenzaldehydeHCID 77337(2-Nitrophenyl)acetic acid

生成物 1

HCID 541417492,6-Di-tert-butyl-4-(2-nitrostyryl)phenol収率 62.9%

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

To a solution of 3,5-di-tert-butyl-4-hydroxybenzaldehyde (8.09 g, 34.5 mmol) and 2-nitrophenylacetic acid (9.40 g, 51.9 mmol) in xylene (60 ml) was added piperidine (0.3 ml) and the mixture was heated under reflux for 26 hrs while removing water producing with the progress of reaction. After allowing to stand overnight, hexane was added to afford as crystals 2,6-di-tert-butyl-4-(2-nitrostyryl)phenol (7.67 g, 62.9%).

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 26 hrs
  3. customwhile removing water producing
  4. customwith the progress of reaction

出典と根拠

ORDレコード
ord-3925ace3a9be4734b0ae067507043c4f
出典データセット
uspto-grants-1997_04
特許番号
US05621010

関連ノート

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