1-Bromopentane → N-allyl-N-pentylphenylamine

HRID 53865

反応式

HRID 53865 の反応式
[CH2:1]([NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH:2]=[CH2:3].Br[CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[OH-].[Na+]>O>[CH2:1]([N:4]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[CH:2]=[CH2:3]

参加物

5

反応物 3

HCID 80571-BromopentaneHCID 14798Sodium HydroxideHCID 68525N-Allylaniline

生成物 1

HCID 10608235N-allyl-N-pentylphenylamine収率 56.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

N-Allylphenylamine (1.95 g, 14.7 mmol) and bromopentane (2.22 g, 14.7 mmol) were stirred at 80° C. for 16 hours. After cooled to room temperature, the mixture was treated with a solution of sodium hydroxide(714 mg, 17.9 mmol) in water (1.5 ml), stirred for 30 minutes and extracted with ether (80 ml). The extract was dried over potassium carbonate, filterd and concentrated in vacuum. The residue was chromatographed on silica gel to give N-allyl-N-pentylphenylamine (1.68 g) in 56% yield as a colorless oil.

後処理

  1. extractionextracted with ether (80 ml)
  2. dry with materialThe extract was dried over potassium carbonate, filterd
  3. concentrationconcentrated in vacuum
  4. customThe residue was chromatographed on silica gel

出典と根拠

ORDレコード
ord-90f2201b01fd4803b47ce102150f4fd9
出典データセット
uspto-grants-1997_04
特許番号
US05621084

関連ノート

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