Ethanol → (Hexahydro-1H-furo[3,4-c]pyrrol-3a-yl)methanamine
反応式
[NH2:1][CH2:2][C:3]12[CH2:10][NH:9][CH2:8][CH:7]1[CH2:6]C[CH2:4]2.C([OH:13])C>[Pd]>[NH2:1][CH2:2][C:3]12[CH2:10][NH:9][CH2:8][CH:7]1[CH2:6][O:13][CH2:4]2参加物
4
実験手順
2.8 g (12.1 mmol) of 1-aminomethyl-7-azabicyclo[3.3.0]octane are dissolved in 50 ml of ethanol and hydrogenated on 0.3 g of palladium-active charcoal at 100° C. and 100 bar. The catalyst is filtered off with suction and the filtrate is concentrated and distilled. Yield: 1.5 g (87% of theory) Boiling point: 70°-72° C./0.03 mbar.
後処理
- filtrationThe catalyst is filtered off with suction
- concentrationthe filtrate is concentrated
- distillationdistilled
出典と根拠
- ORDレコード
- ord-b30132afecb2478d999c28d547f5e513
- 出典データセット
- uspto-grants-1997_04
- 特許番号
- US05621105
反応ノート
読み込み中…