Hydrochloric Acid → 4-Methyl-2-methylene valeric acid

HRID 538856

反応式

HRID 538856 の反応式
[CH2:1]([C:5](=[CH2:11])[C:6]([O:8]CC)=[O:7])[CH:2]([CH3:4])[CH3:3].Cl>[OH-].[K+]>[CH2:1]([C:5](=[CH2:11])[C:6]([OH:8])=[O:7])[CH:2]([CH3:4])[CH3:3]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 10909818Ethyl 4-methyl-2-methylenepentanoate

生成物 1

HCID 1686594-Methyl-2-methylene valeric acid収率 99.1%

試薬・触媒・溶媒 1

HCID 14797Potassium Hydroxide溶媒

実験手順

Saponification of 6.32 g (40.4 mmol) ethyl 2-isobutylacrylate was carried out 50 ml of 20% aqueous KOH at reflux. The obtained mixture was acidified by aqueous HCl to pH=5-6, and the product was extracted by 2×100 ml of dichloromethane. The organic extract was evaporated to dryness to give 5.13 g (99%) 2-isobutylacrylic acid which was further used without an additional purification.

後処理

  1. temperatureat reflux
  2. extractionthe product was extracted by 2×100 ml of dichloromethane
  3. extractionThe organic extract
  4. customwas evaporated to dryness

出典と根拠

ORDレコード
ord-61225128229a48d3a3819e2eb4be8673
出典データセット
uspto-grants-2014_10
特許番号
US08865848B2

関連ノート

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