Sodium borohydride → N-(4-(2-(dimethylamino)-1-hydroxybutyl)phenyl)acetamide

HRID 538865ノート

反応式

HRID 538865 の反応式
[CH3:1][N:2]([CH3:18])[CH:3]([CH2:16][CH3:17])[C:4]([C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13](=[O:15])[CH3:14])=[CH:8][CH:7]=1)=[O:5].[BH4-].[Na+]>CO>[CH3:18][N:2]([CH3:1])[CH:3]([CH2:16][CH3:17])[CH:4]([C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13](=[O:15])[CH3:14])=[CH:8][CH:7]=1)[OH:5]

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 86681892N-(4-(2-(dimethylamino)butanoyl)phenyl)acetamide

生成物 1

HCID 86681893N-(4-(2-(dimethylamino)-1-hydroxybutyl)phenyl)acetamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Step-4: A solution of N-(4-(2-(dimethylamino)butanoyl)phenyl)acetamide (3.80 g, 15.30 mmol) in 40 mL MeOH was cooled in an ice bath under N2 and treated with NaBH4 (725 mg, 19.12 mmol), added in one portion. The reaction vessel was removed from the ice bath and stirred at rt over the weekend. The reaction was quenched with acetone, then concentrated in vacuo and partitioned between DCM and half-saturated NaHCO3. The aqueous phase was extracted four times with DCM and the organic extracts were combined and dried over Na2SO4. The solution was decanted and concentrated in vacuo. The solid residue was purified by silica gel column chromatography eluting with 10%-12% MeOH (2N NH3)/DCM to provide the syn-isomer of N-(4-(2-(dimethylamino)-1-hydroxybutyl)phenyl)acetamide as a white amorphous solid and the anti-isomer as a straw colored oil. MS ESI: m/z 251.17 [M+1+].

後処理

  1. additionadded in one portion
  2. customThe reaction vessel was removed from the ice bath
  3. customThe reaction was quenched with acetone
  4. concentrationconcentrated in vacuo
  5. custompartitioned between DCM and half-saturated NaHCO3
  6. extractionThe aqueous phase was extracted four times with DCM
  7. dry with materialdried over Na2SO4
  8. customThe solution was decanted
  9. concentrationconcentrated in vacuo
  10. customThe solid residue was purified by silica gel column chromatography
  11. washeluting with 10%-12% MeOH (2N NH3)/DCM

出典と根拠

ORDレコード
ord-b871e9a5ea5947a59e7409afbc3921da
出典データセット
uspto-grants-2014_10
特許番号
US08865752B2

反応ノート

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