Water → 6-Butyl-benzothiazol-2-ylamine

HRID 538890ノート

反応式

HRID 538890 の反応式
[CH2:1]([C:5]1[CH:11]=[CH:10][C:8]([NH2:9])=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].[C:12]([S-:14])#[N:13].[K+].BrBr.O>C(O)(=O)C>[CH2:1]([C:5]1[CH:6]=[CH:7][C:8]2[N:9]=[C:12]([NH2:13])[S:14][C:10]=2[CH:11]=1)[CH2:2][CH2:3][CH3:4]

参加物

6

反応物 4

HCID 962WaterHCID 76944-ButylanilineHCID 24408BromineHCID 516872Potassium thiocyanate

生成物 1

HCID 15892106-Butyl-benzothiazol-2-ylamine

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

実験手順

Step-1: To a mixture of 4-butylaniline 67 mmol) and KSCN (26 g, 268 mmol) in acetic acid was added Br2 in acetic acid (70 mL) dropwise over 6 min at RT. The mixture was stirred at RT overnight and poured into water (2 L). The precipitate was collected, washed with water and dried to afford 6-butylbenzo[d]thiazol-2-amine. MS (ESI+) m/z 207.20 [M+H]+

後処理

  1. customThe precipitate was collected
  2. washwashed with water
  3. customdried

出典と根拠

ORDレコード
ord-2f3844f8b86640e18bac4e2d12282a14
出典データセット
uspto-grants-2014_10
特許番号
US08865752B2

反応ノート

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