Hydrochloric Acid → 2-Aminophenol hydrochloride

In a preferred embodiment of the present invention, in step (a), the 2-aminophenol solution may be maintained at a pH of 2-5 while hydrochloride gas is added thereto, and as a result, 2-aminophenol hydrochloride can be obtained in solid form. In step (b), the solution of 2-aminophenol hydrochloride in ethanol may be reacted with isopentyl nitrite at about −5° C. to make the nitramide intermediate. In step (c), the solution of the intermediate in ethanol may be added slowly to the ethanol solution containing para-toluenesulfonic acid (PTSA or TsOH) and tin chloride (SnCl2) at low temperature (−5° C.), thereby obtaining 2-hydrazinylphenol tosylate.

1. additionis added

ORDレコード

ord-0400ba93ba6b4c43a18a5ad8f15a7e51

出典データセット

uspto-grants-2014_10

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08865934B2